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Abstract #5356

Different Models of Ultra-high b-Value DWI for Better Detection of Restricted Diffusion

Qiqi Tong1, Hongjian He1, Tianyi Qian2, Yi Sun3, Ting Gong1, and Jianhui Zhong1

1Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, 2MR Collaboration NE Asia, Siemens Healthcare, Beijing, China, 3MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China

Diffusion-weighted imaging with high b-value can potentially capture the restricted diffusion in tissues. With high-b-value diffusion weighting, the signal in tissue decays non-exponentially, thus the expansion of DWI signal usually be interpreted at second order or higher. However, in the ultra-high b-value (b>4k s/mm2), the cumulant expansion of higher order would fail to fit the signal. In this study, DTI, DKI, biexponential and Kärger models were used for approximating DWI signals with ultra-high b-values.

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