Abstract #5367

Impact of time-of-day on diffusivity measures of brain tissue derived from diffusion tensor imaging

Cibu Thomas¹, Neda Sadeghi², Aaron Trefler¹, Joelle Sarlls³, Chris Baker¹, and Carlo Pierpaoli²

¹National Institute of Mental Health, Bethesda, MD, United States, ²National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, United States, ³National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States

Although diurnal fluctuations in DTI-based measures of brain tissue properties have been reported, the underlying mechanism has not been investigated. Here, we processed multi-shell diffusion data using the conventional monoexponential tensor model as well as with a dual-compartment tensor model and assessed whether, time-of-day (TOD) fluctuations in DTI measures are due to changes in the magnitude of a CSF-like water compartment, or due to changes in the diffusion properties of parenchymal water. Our results suggest that TOD effects are due to fluctuations in the magnitude of a CSF-like water compartment rather than changes in the diffusion properties of parenchymal water.

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