Radiation induced white matter changes are well known and vastly studied. However, radiation induced gray matter alterations are still a research question. In the present study, DTI based gray matter changes in C57BL/6 mice were studied following cranial and whole body irradiation at 5 Gy during sub acute and early delayed time point. Longitudinal changes in FA and MD were observed till 8 months post radiation. Comparative analysis depicted differential response after cranial and whole body radiation exposure with prominent alterations in cranially irradiated animals. with most changes at 8 months post irradiation
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