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Abstract #5375

Oscillating Gradient Spin Echo Diffusion Tensor MRI of Acute Human Stroke

Christian Beaulieu1, Leka Sivakumar2, Ken Butcher2, Sarah Treit1, Derek Emery3, and Robert Stobbe1

1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Neurology, University of Alberta, Edmonton, AB, Canada, 3Radiology, University of Alberta, Edmonton, AB, Canada

Different spatial scales of micro-structural alteration with disease can be interrogated by varying the time water has to interact with its surroundings (e.g. membranes, etc). Oscillating gradient spin echo (OGSE) diffusion MRI enables much shorter diffusion times (e.g. 6 ms) than typical pulsed gradient spin-echo (PGSE) (e.g. 40 ms). The large diffusion reduction typically observed with PGSE in ischemic lesions in human stroke was markedly less with OGSE, and the OGSE-PGSE difference was greatest for radial diffusivity in ischemic white matter. This result is consistent with the swelling and beading of the axons underlying diffusion contrast in cerebral ischemia.

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