Abstract #5376

Non-invasive quantification of inflammation, axonal and myelin injury in MS: a 7T DBSI study

Simona Schiavi¹, Peng Sun², Sirio Cocozza³, Maria Petracca⁴, Mohamed Mounir El Mendili⁴, Kornelius Podranski⁴, Matilde Inglese^1,4, and Sheng-Kwei Song^2,5,6,7

¹DINOGMI, University of Genoa/IRCCS AOU San Martino-IST, Genoa, Italy, ²Radiology, Washington University School of Medicine, St. Louis, MO, United States, ³Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy, ⁴Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States, ⁶Biomedical Engineering, Washington University, St. Louis, MO, United States, ⁷Biomedical MR Laboratory, Washington University School of Medicine, St. Louis, MO, United States

Diffusion basis spectrum imaging (DBSI) has successfully distinguished co-existing pathological processes in CNS diseases, such as multiple sclerosis (MS). The aim of our study was to determine the feasibility of DBSI in MS patients at 7T and to investigate the underlying pathological substrates of different lesion types and normal appearing white matter (NAWM).

For the first time, we proved the feasibility of DBSI at 7T, validating the specificity of the different metrics to diverse pathological substrates. Additionally, we employed DBSI metrics to characterize focal and diffuse tissue damage in different MS phenotypes, confirming their utility as biomarkers of tissue-specific microstructural damage.

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