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Abstract #5377

Diffusion Basis Spectrum Imaging and Diffusion Tensor Imaging in Mouse Model of Traumatic Brain Injury

Harri Merisaari1, Tsen-Hsuan Lin1, Gentian Toshkezi2, Michele Kyle2, Zhao Li-Ru2, and Sheng-Kwei Song1

1Mallinckrodt Institute of Radiology, St. Louis, MO, United States, 2Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY, United States

Traumatic brain injury (TBI) is a major cause of acquired brain injury in both children and adults. Traumatic axonal injury (TAI) is a major contributor to cognitive dysfunction followed by TBI. Diffusion Tensor Imaging (DTI) has shown to characterize TAI in non-invasive manner. However, DTI as a gross measure has limitations in its parameters in detection capability of underlying pathologies. Diffusion Basis Spectrum Imaging (DBSI) is an advanced imaging technique that has been applied to investigate nervous system pathology. Accurate characterization of brain pathologies in vivo, such as axonal injury, is extremely important in the study of changes that occur over time after TBI. To investigate these two methods in TBI data, we performed a comparison in mouse model between control and injured groups.

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