Abstract #5386

Alterations in white matter connectivity related to language comprehension in patients with Crohn’s disease in remission

Jiancheng Hou¹, Keith Dodd¹, Veena Nair¹, Poonam Beniwal-Patel², Vivek Prabhakaran¹, and Sumona Saha³

¹Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Medicine, Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, United States, ³Department of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin-Madison, Madison, WI, United States

Reduced white matter integrity in patients with Crohn’s disease (CD) has been previously reported. However few studies have examined the behavioral implications of compromised WM integrity in these patients. Here we report results from an exploratory study investigating group differences in diffusivity measures in patients with Crohn’s disease in remission [compared to age and gender matched healthy control (HC) subjects] and examined their relationship to participants’ performance on a phonemic fluency task. CD patients demonstrate altered brain microstructural changes in regions associated with several cognitive functions including language processing.

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