Abstract #5387

Alteration in Diffusion Characteristic of Cerebrospinal Fluid after Neurological Disease in Rats

Jun Tazoe¹, Yu-Chieh Jill Kao^1,2, Chia-Feng Lu^1,3, Ping-Huei Tsai^1,2, Fei-Ting Hsu^1,2, Bao-Yu Hsieh⁴, and Cheng-Yu Chen^1,2

¹Research Center of Translational Image, Teipei Medical University, Taipei, Taiwan, ²Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ³Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ⁴Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan

While the quantitative maps conducted by diffusion weighted or diffusion tensor imaging were applied to the brain parenchyma to describe the tissue type and fate, the diffusion coefficient in the cerebrospinal fluid (CSF) was not well explored. In this study, significant lower mean of diffusion constant (D-value) and change in the histogram of D-value were observed in stroke animals compared with intact rats and the mTBI animals, suggesting the brain lesion or damage may alter the diffusion characteristics in CSF.

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