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Abstract #5394

Normalised Grey Matter and White Matter Volumes in the Neurologically Intact Conus Medullaris

Marios C Yiannakas1, Martina D Liechti1,2, Patrick Cullinane1, Xixi Yang1,2, Ahmed T Toosy1, Jalesh N Panicker2, and Claudia Angela Gandini Wheeler-Kingshott1,3,4

1Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2Uro-Neurology, The National Hospital for Neurology and Neurosurgery and UCL Institute of Neurology, London, United Kingdom, 3MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy, 4Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

Magnetic Resonance Imaging derived measures of spinal cord (SC) grey matter (GM) and white matter (WM) volume are useful for indirectly assessing neurodegeneration over time (i.e. atrophy). However, for the correct interpretation of such morphometric analyses, one must take into consideration the natural variability that exists between subjects, which is unrelated to a disease process. Various normalisation strategies have been proposed for use in the upper SC, but evidence from similar applications in the lower SC is currently lacking. In this work, we present our first approach to normalisation of GM/WM volumes in the neurologically intact conus medullaris.

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