This is the first in vivo study to investigate major phosphorus metabolites of human parotid gland with 31P magnetic resonance spectroscopy (MRS) using 3D chemical shift imaging (CSI) technique. Five healthy volunteers were measured on a clinical 3.0 T MRI scanner, and three of them were remeasured immediately after intake of tablets containing vitamin C. The spectra reveal large adenosine triphosphate (ATP) and phosphocreatine (PCr) intensities. Following intake of tablets containing vitamin C, decrease of β-ATP can be observed. In vivo 31P MRS can be used to assess bioenergetics of the human parotid gland within a reasonable scan time.
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