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Abstract #5415

Working memory training and brain structural and functional correlates in children born preterm

Claire Kelly1, Deanne Thompson1,2,3, Jian Chen1,4, Elisha Josev1, Leona Pascoe1, Megan Spencer-Smith1,5, Chris Adamson1, Chiara Nosarti6, Lex Doyle1,2,7,8, Marc Seal1,2, and Peter Anderson1,2,5

1Murdoch Children's Research Institute, Melbourne, Australia, 2Department of Paediatrics, The University of Melbourne, Melbourne, Australia, 3Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 4Department of Medicine, Monash Medical Centre, Monash University, Melbourne, Australia, 5Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Australia, 6King's College London, London, United Kingdom, 7Newborn Research, The Royal Women's Hospital, Melbourne, Australia, 8Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia

In a randomised controlled trial, we investigated if adaptive, computerised working memory training using Cogmed was associated with greater neural changes compared with a placebo training program. Participants were a population-based cohort of 91 school-age children born <28 weeks’ gestation or <1000 g birthweight. Children had structural, diffusion and task-based functional MRI before and two weeks following five weeks of Cogmed or placebo. There was little evidence for larger changes in cortical morphometry, white matter microstructure, or brain functional activity following Cogmed compared with placebo. In our study, Cogmed did not benefit brain structure or function in preterm-born children.

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