Very preterm infants (<32 weeks gestational age) are at high risk for motor impairments. Investigation of brain network connectivity will improve our understanding of how brain organizational changes influence motor function and can result in improved individual risk stratification. In this work, we found reduction in functional connectivity in multiple motor and sensory regions, soon after birth, in very preterm infants at high risk of motor impairments assessed at 2 years of age. Our findings may enable mechanistic understanding and facilitate early, more accurate prediction of motor impairments.
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