Abstract #5417

Prevalence of brain lesions in a contemporary cohort of newborns with complex congenital heart disease prior to surgery

Christopher Kelly¹, Catarina Tristão Pereira¹, Sophie Arulkumaran¹, Lucilio Cordero Grande¹, Emer Hughes¹, Rui Pedro A. G. Teixeira¹, Johannes Steinweg¹, Joseph V Hajnal¹, John Simpson², A. David Edwards¹, Mary A Rutherford¹, and Serena J Counsell¹

¹Centre for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, ²Paediatric Cardiology Department, Evelina Children's Hospital, London, United Kingdom

Infants born with congenital heart disease (CHD) are known to experience a distinct pattern of neurodevelopmental and behavioural impairment in later life. In this study, we scanned 64 infants with complex CHD prior to surgery, and used high-resolution structural, diffusion and susceptibility-weighted magnetic resonance imaging to understand the burden of brain lesions in a contemporary cohort. We characterised lesions and produced quantitative lesion maps, registered to a population template. We found a lower incidence of infarction than has been reported in previous comparable cohorts, and we explore the clinical reasons that may explain such variation.

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