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Abstract #5417

Prevalence of brain lesions in a contemporary cohort of newborns with complex congenital heart disease prior to surgery

Christopher Kelly1, Catarina Tristão Pereira1, Sophie Arulkumaran1, Lucilio Cordero Grande1, Emer Hughes1, Rui Pedro A. G. Teixeira1, Johannes Steinweg1, Joseph V Hajnal1, John Simpson2, A. David Edwards1, Mary A Rutherford1, and Serena J Counsell1

1Centre for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 2Paediatric Cardiology Department, Evelina Children's Hospital, London, United Kingdom

Infants born with congenital heart disease (CHD) are known to experience a distinct pattern of neurodevelopmental and behavioural impairment in later life. In this study, we scanned 64 infants with complex CHD prior to surgery, and used high-resolution structural, diffusion and susceptibility-weighted magnetic resonance imaging to understand the burden of brain lesions in a contemporary cohort. We characterised lesions and produced quantitative lesion maps, registered to a population template. We found a lower incidence of infarction than has been reported in previous comparable cohorts, and we explore the clinical reasons that may explain such variation.

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