Abstract #5418

Multicentre pediatric brain tumour dynamic susceptibility contrast (DSC-) MRI with contrast agent leakage correction

Stephanie Withey^1,2,3, Jan Novak⁴, Lesley MacPherson⁵, Laurence Abernethy⁶, Barry Pizer⁷, Richard Grundy⁸, Simon Bailey⁹, Dipayan Mitra¹⁰, Theodoros Arvanitis^2,3,11, Dorothee Auer¹², Shivaram Avula⁶, and Andrew Peet^2,3

¹RRPPS, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ²Oncology, Birmingham Children's Hospital, Birmingham, United Kingdom, ³Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom, ⁴Aston University, Birmingham, United Kingdom, ⁵Radiology, Birmingham Children's Hospital, Birmingham, United Kingdom, ⁶Radiology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, ⁷Oncology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, ⁸The Children’s Brain Tumour Research Centre, University of Nottingham, Nottingham, United Kingdom, ⁹Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom, ¹⁰Neuroradiology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ¹¹Institute of Digital Healthcare, University of Warwick, Coventry, United Kingdom, ¹²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Dynamic susceptibility contrast (DSC-) MRI provides measures of relative cerebral blood volume (rCBV) in pediatric brain tumors. Correction of rCBV for the effects of contrast agent leakage can be done using post-processing techniques. Forty pediatric patients with high and low grade tumors underwent DSC-MRI scans pre-treatment at four centers. DSC-data was analyzed with and without leakage correction to calculate rCBV and the leakage parameter, K2. There were significant differences between all parameters when comparing the high and low grade tumor groups. Low grade tumors tended to show T1-dominant leakage effects while high grade tumors showed predominantly T2* dominance.

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