Abstract #5419

Brain growth over the first 13 years of life in typically developing and very preterm children

Deanne Thompson^1,2,3,4, Lillian Matthews⁵, Bonnie Alexander^1,2, Katherine Lee^1,3,6, Claire Kelly^1,2, Rod Hunt^1,3,7, Jeanie Cheong^1,8,9, Megan Spencer-Smith^1,10, Marc Seal^2,3, Jeffrey Neil⁵, Terrie Inder^1,5, Lex Doyle^1,3,8,9, and Peter Anderson^1,3,10

¹Victorian Infant Brain Studies (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia, ²Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, ³Department of Paediatrics, The University of Melbourne, Melbourne, Australia, ⁴Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, ⁵Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, ⁶Clinical Epidemiology & Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia, ⁷Neonatal medicine, The Royal Children's Hospital, Melbourne, Australia, ⁸Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, ⁹Royal Women's Hospital, Melbourne, Australia, ¹⁰Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Australia

Few longitudinal cohort studies exist characterizing regional brain volumes from birth to adolescence. This study derives brain volumes in approximately 100 regions at term-equivalent, 7 and 13 years of age for 102 very preterm and 20 full-term children. The trajectory of brain development in many regions differed between very preterm and full-term children over the first 7 years of life. From 7 to 13 years brain growth slowed, ceased or regressed in both groups in a region-specific manner, apart from subcortical regions that continued to increase in volume. This study provides novel insights in typical and atypical regional brain volumetry.

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