Abstract #5420

A simple semi-quantitative scale for brain MR imaging is associated with motor function, communication and cognition in dyskinetic cerebral palsy

Olga Laporta-Hoyos^1,2,3, Simona Fiori^4,5, Kerstin Pannek⁶, Julia Ballester-Plane¹, David Leiva⁷, Lee B Reid⁶, Alex M Pagnozzi⁶, Elida Vázquez⁸, Ignacio Delgado⁸, Alfons Macaya⁹, Roser Pueyo¹, and Roslyn N Boyd¹⁰

¹Departament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, Spain, ²Institut de Neurociències. Universitat de Barcelona, Barcelona, Spain, ³Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Barcelona, Spain, ⁴IRCCS Stella Maris, Pisa, Italy, ⁵The University of Pisa, Pisa, Italy, ⁶Australian e-Health Research Centre. Commonwealth Scientific and Industrial Research Organisation, Brisbane, Australia, ⁷Departament de Psicologia Social i Psicologia Quantitativa, Universitat de Barcelona, Barcelona, Spain, ⁸Servei de Radiologia Pediàtrica. Hospital Universitari Vall d'Hebron, Barcelona, Spain, ⁹Grup de Recerca en Neurologia Pediàtrica. Vall d'Hebron Institut de Recerca. Universitat Autònoma de Barcelona., Barcelona, Spain, ¹⁰Queensland Cerebral Palsy and Rehabilitation Research Centre. Faculty of Medicine. The University of Queensland, Brisbane, Australia

Previous neuroimaging studies of DCP have been based on categorical descriptors or advanced neuroimaging protocols that cannot be easily utilised in a clinical context. To enable clinical translation, we characterized brain lesions, and their association with clinical outcomes in 39 participants with DCP, using a semi-quantitative scale for brain MRI that is clinically accessible due to its relative simplicity and reliance only on standard clinical images. Our results indicate that (A) ventral posterior lateral thalamus and frontal lobe are the most frequent locations of observable lesions in DCP and that (B) sqMRI can index motor, communication and cognitive functioning.

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