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Abstract #5420

A simple semi-quantitative scale for brain MR imaging is associated with motor function, communication and cognition in dyskinetic cerebral palsy

Olga Laporta-Hoyos1,2,3, Simona Fiori4,5, Kerstin Pannek6, Julia Ballester-Plane1, David Leiva7, Lee B Reid6, Alex M Pagnozzi6, Elida Vázquez8, Ignacio Delgado8, Alfons Macaya9, Roser Pueyo1, and Roslyn N Boyd10

1Departament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, Spain, 2Institut de Neurociències. Universitat de Barcelona, Barcelona, Spain, 3Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Barcelona, Spain, 4IRCCS Stella Maris, Pisa, Italy, 5The University of Pisa, Pisa, Italy, 6Australian e-Health Research Centre. Commonwealth Scientific and Industrial Research Organisation, Brisbane, Australia, 7Departament de Psicologia Social i Psicologia Quantitativa, Universitat de Barcelona, Barcelona, Spain, 8Servei de Radiologia Pediàtrica. Hospital Universitari Vall d'Hebron, Barcelona, Spain, 9Grup de Recerca en Neurologia Pediàtrica. Vall d'Hebron Institut de Recerca. Universitat Autònoma de Barcelona., Barcelona, Spain, 10Queensland Cerebral Palsy and Rehabilitation Research Centre. Faculty of Medicine. The University of Queensland, Brisbane, Australia

Previous neuroimaging studies of DCP have been based on categorical descriptors or advanced neuroimaging protocols that cannot be easily utilised in a clinical context. To enable clinical translation, we characterized brain lesions, and their association with clinical outcomes in 39 participants with DCP, using a semi-quantitative scale for brain MRI that is clinically accessible due to its relative simplicity and reliance only on standard clinical images. Our results indicate that (A) ventral posterior lateral thalamus and frontal lobe are the most frequent locations of observable lesions in DCP and that (B) sqMRI can index motor, communication and cognitive functioning.

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