Abstract #5425

The Impact of Prenatal Endocrine-Disrupting-Chemical Exposure on Brain Function in Teenagers

Chi-Ieong Hong¹, Shu-Li Wang², Chao-Yu Shen^1,3, Jeng-Dau Tasi⁴, Tou-Rong Chen¹, and Jun-Cheng Weng^5,6

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan, ³Institute of Medicine and Department of Medical Imaging, Chung Shan Medical University and Hospital, Taichung, Taiwan, ⁴School of Medicine and Department of Pediatrics, Chung Shan Medical University and Hospital, Taichung, Taiwan, ⁵Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, ⁶Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan

The products made by endocrine disrupting chemicals (EDCs) widely exists in our daily life, which could be a risk of our health. We tried to find the relationship between prenatal exposure to EDCs’ concentrations and teenager’s brain function using resting-state functional MRI (rs-fMRI). Our results showed the correlation between prenatal perfluorononanoic acid (PFNA)/MeHg exposure and functional alterations of the teenage brain in caudate gyrus and putamen.

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