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Abstract #5426

Assessment of myelination in developing brains by using the inhomogeneous magnetization transfer MRI

Xianjun Li1,2, Yuli Zhang1, Fan Wu1, Xiaoqian Jia1, Xiaoyu Wang1, Chao Jin1, Qinli Sun1, Heng Liu1,2, Xiaocheng Wei3, and Jian Yang1,2

1Department of Radiology, the First Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China, 2Department of Biomedical Engineering, the Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China, 3MR Research China, GE Healthcare, Beijing, China

In vivo assessment of myelination is critical for understanding the typical and pathological brain development. Inhomogeneous magnetization transfer (ihMT) has been proposed recently and may be useful to quantify myelin contents. This study tried to evaluate performances of magnetization transfer ratio (MTR) and ihMT ratio (ihMTR) in assessing the myelination of toddler and adolescent brains. The ihMTR maps hold larger image contrasts than MTR maps. Moreover, ihMTR demonstrates larger relative changes during the period from the toddler to adolescent. Results in this study suggested that ihMTR was specific for characterizing white matter and sensitive to myelination during the brain development.

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