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Abstract #5428

Late post-natal brain metabolic changes in healthy rats, a longitudinal in vivo 1H and 31P MRS study

Veronika Rackayova1, Olivier Braissant2, Rolf Gruetter3, Valerie McLin4, and Cristina Cudalbu3

1Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Neurometabolic Unit, Service of Clinical Chemistry, University Hospital of Lausanne, Lausanne, Switzerland, 3Centre d’Imagerie Biomédicale (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Swiss Center for Liver Disease in Children, University Hospitals Geneva, Geneva, Switzerland

New-born rats are known to undergo important brain metabolic changes during first 4-5 weeks of their lives. However precise description of metabolic changes at latter stages is missing. At this period rats might still undergo changes due to final brain maturation what may impact data interpretation of experiments during this window. This study aimed to explore possible metabolic changes in the rat brain during the late post-natal period (post-natal days 29 - 77), using in-vivo 1H and 31P-MRS and a temporal resolution of 1 week. We report significant changes in Ins, tCho (mainly due to GPC increase), Tau and Glu in rats considered as young adults.

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