Abstract #5430

In vivo 1H NMR spectroscopy study of mitochondrial pyruvate carrier 1 (MPC1) deficient mouse reveals energy shift in the development of embryonic brain

Hongxia Lei^1,2, Zeinab Ammar², Corina M Berset¹, and Jean-Claude Martinou²

¹Center for Biomedical Imaging (CIBM-AIT), École Polytechnique Fédérale de Lausanne, Lasuanne, Switzerland, ²University of Geneva, Geneva, Switzerland

Pyruvate degradation is an important step for oxidative phosphorylation. We studied brains of murine embryos devoid of mitochondrial pyruvate carrier 1 (MPC1) using ¹H MRS. We demonstrates that after the embryonic energy shift, lactate accumulation can explain embryonic lethality in embryo devoid of MPC1.

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