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Abstract #5431

Differential effects of hunger and depression on cerebral blood flow in healthy adolescents

Céline Charroud1,2, Emmanuelle Le Bars2, Emily Sanrey1,3, Jérémy Deverdun2, Josef Pfeuffer4, Nicolas Menjot de Champfleur2, and Philippe Coubes1,3

1Unité de recherche sur les comportements et mouvements anormaux (URCMA, IGF, INSERM U661 UMR 5203), Departments of neurosurgery, Montpellier University Hospital Center, Gui de Chauliac Hospital, University of Montpellier, Montpellier, France, 2Institut d’Imagerie Fonctionnelle Humaine, I2FH, Department of Neuroradiology, Montpellier University Hospital Center, Gui de Chauliac Hospital, University of Montpellier, Montpellier, France, 3Unité de pathologie cérébrale résistante, Department of neurosurgery, Montpellier University Hospital Center, Montpellier, France, 4Siemens Healthcare GmbH, Application Development, Erlangen, Germany

This study aims to explore the appetite effect on taste and depression on healthy adolescents using Arterial Spin Labeling. Fifteen participants complete the Multiscore Depression Inventory for Children test and two MRI sessions: pre-lunch (hunger) and post-lunch (satiety). We found an increased CBF – cerebral blood flow – during hunger in the posterior insula (anticipation and motivation of feeding) and during satiation in the precuneus, lingual gyrus and cuneus (inhibition pattern of food intake). We show that the correlations between depression and CBF are modulated by appetite in the precuneus, operculum, lingual, cuneus, middle frontal gyrus and inferior parietal lobule.

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