Abstract #5432

Influences of the Gut Microbiome on Early Brain Development

Douglas C Dean¹, Elizabeth M Planalp^1,2, Nicholas Vogt³, Kristin Dowe^1,2, Alysha Rameshk¹, Kristine Mclaughlin¹, Abigail Freeman¹, and Andrew L Alexander^1,4,5

¹Waisman Center, University of Wisconsin Madison, Madison, WI, United States, ²Psychology, University of Wisconsin Madison, Madison, WI, United States, ³Medicine, University of Wisconsin Madison, Madison, WI, United States, ⁴Psychiatry, University of Wisconsin Madison, Madison, WI, United States, ⁵Medical Physics, University of Wisconsin Madison, Madison, WI, United States

Increasing evidence from animal studies suggests the gut microbiome has a significant role on early brain development and function. However, little is known about this role on human brain development and in particular, on myelination. Using quantitative multicomponent relaxometry and 16S rRNA sequencing, we examined measures of myelin content and the gut microbiome from a cohort of typical developing infants. Infant brain measures were found to be differentially associated with the relative abundancies of certain bacteria phylum, suggesting that microbial communities may have a significant influence on processes of early brain development.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.