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Abstract #5433

Establishing a developmentally appropriate fMRI paradigm for presurgical mapping of memory in children

Amanda G Wood1, Elaine Foley2, Parnpreet Virk2, Helen Ruddock3, Paras Joshee4, Kelly Murphy2, and Stefano Seri2

1Life and Health Sciences, Aston Brain Centre, Aston University, Birmingham, United Kingdom, 2Aston University, Birmingham, United Kingdom, 3University of Liverpool, Liverpool, United Kingdom, 4University of Birmingham, Birmingham, United Kingdom

The use of functional MRI to evaluate risk to memory function following temporal lobe surgery in children cannot rely on adult tools. We present a novel fMRI paradigm that is brief, independent of reading ability, and therefore a candidate for presurgical evaluation. Data from 36 adults and 19 children (all healthy controls) show that the paradigm captures the expected leftward asymmetry of mesial temporal activation in adults. A more symmetrical pattern is observed in children, consistent with the emergence of hemispheric specialisation across childhood. These data have important implications for the interpretation of presurgical memory fMRI in the paediatric setting.

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