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Abstract #5434

Trajectories of brain lactate and energy metabolite concentrations do not contribute to elevated aerobic glycolysis across childhood

Helene Benveniste1, Gerald Dienel2, Zvi Jacob3, Hedok Lee1, Rany Makaryus3, Albert Gjedde4, Fahmeed Hyder5, and Douglas L. Rothman5

1Anesthesiology, Yale School of Medicine, New Haven, CT, United States, 2Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 3Anesthesiology, Stony Brook Medicine, Stony Brook, NY, United States, 4Panum Institute, University of Copenhagen, Copenhagen, Denmark, 5Department of Biomedical Engineering & Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States

Lactate is produced in normal brain even when O2 levels are ample, and high lactate production may explain aerobic glycolysis (AG) in developing brain. We evaluated steady state lactate concentrations ([Lac]) in brains of 87 children using 1HMRS while they underwent routine MRI examination. The trajectory of [Lac] in cerebral cortex across childhood was below the 0.5-0.7 mM range in normal adult brain. Thus, lactate accumulation and efflux are unlikely to underlie excessive AG in children.

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