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Abstract #5456

A comprehensive investigation of physiologic noise modeling in resting state fMRI; phase shifted cardiac response function in EPI

Wanyong Shin1 and Mark J Lowe1

1Radilogy, Cleveland Clinic, Cleveland, OH, United States

The cardiac and respiratory response functions derived from RETROICOR have substantial variation. In this study, we investigate the source of this variation. We found the cardiac response function is phase or time shifted across the brain while the respiratory function has a fixed phase, but changes polarity across the brain. We further investigated the efficacy of physiologic noise correction accounting for this with a single response function model.

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