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Abstract #5457

Novel multi-slab GRASE sequences for fMRI. Comparison with EPI.

Djaudat Idiyatullin1, Wei Zhu1, Yi Zhang1, Xiao-Hong Zhu1, Wei Chen1, and Kâmil Uğurbil1

1Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

T2 weighted fMRI has been shown to provide higher spatial specificity than commonly used T2* contrast. However, 2D-spin-echo-EPI method, which is the most commonly employed approach, suffers from a low functional mapping contrast. Versions of single-shot 3D-GRASE sequence provide improvements in fMRI contrast, but suffer limitations particularly at ultrahigh magnetic fields due to shorter T2. To solve this problem, a new multi-slab version of the 3D-GRASE sequence with and without the capability of inner-volume selection, abbreviated as ivmsGRASE and msGRASE, respectively, are proposed. The theoretical and practical considerations of these methods in comparison with spin-echo-EPI for fMRI application are presented.

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