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Abstract #5460

Correcting for the influence of cerebrospinal fluid in quantification of R2’ and deoxygenated blood volume (DBV) using quantitative BOLD

Matthew T Cherukara1, Alan J Stone2, Michael A Chappell1, and Nicholas P Blockley2

1Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom, 2Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, United Kingdom

Streamlined qBOLD (sqBOLD) can be used to quantify deoxygenated blood volume and the reversible relaxation rate R2’ (used to estimate oxygen extraction fraction), although it is vulnerable to systematic errors from a number of confounding factors including the presence of cerebrospinal fluid (CSF). A FLAIR inversion preparation is typically used to null the CSF signal, but this results in a reduction in SNR, and increases scan time. We present a post-processing method to account for the presence of CSF that has the potential to improve both the accuracy and efficiency of the sqBOLD technique without the need for FLAIR preparation.

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