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Abstract #5489

Accurate measurement of susceptibility and orientation using non-linear signal phase evolution; validation in a phantom experiment

Elena Kleban1, Richard Bowtell1, Penny Gowland1, and Molly Bright1,2

1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom

We validate the use of non-linear signal phase evolution to estimate the susceptibility and orientation of sub-voxel structures. Capillary tubes filled with ferritin solutions of varying susceptibility were positioned in a water phantom. Multi-echo gradient-echo scans (100 echoes, echo-spacing=0.6ms) were acquired for multiple orientations of the capillaries with respect to the magnetic field. Fitting a 2-compartment model to the complex signal, processed using frequency difference mapping (FDM), resulted in susceptibility and signal fraction estimates in good agreement with theoretical predictions. Non-linear phase evolution, processed using FDM, may provide new insight into microvascular structure and physiology.

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