Abstract #5488

Acceleration strategies for whole brain quantitative Magnetization Transfer Imaging

Marco Battiston¹, Francesco Grussu^1,2, Torben Schneider³, Ferran Prados^1,4, Sebastien Ourselin⁴, Claudia Angela Wheeler-Kingshott^1,5,6, and Rebecca Sara Samson¹

¹Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, ²Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ³Philips UK, Surrey, United Kingdom, ⁴Translational Imaging Group, Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London, London, United Kingdom, ⁵Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁶Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy

Methods for quantitative measurement of myelin are of great interest for understanding brain tissue microstructure, and have potentially important implications in clinical settings for improved diagnosis and prognosis in demyelinating diseases. Quantitative Magnetization Transfer (qMT) has been proposed as a sensitive MRI technique for myelin mapping in the central nervous system. However, after an initial wave of interest, it has never found a successful translation into a clinical scenario, mostly due to its prohibitive scan time. Here we investigate solutions to promote the development of fast qMT protocols including simultaneous multi-slice EPI, and provide preliminary results in vivo.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.