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Abstract #5488

Acceleration strategies for whole brain quantitative Magnetization Transfer Imaging

Marco Battiston1, Francesco Grussu1,2, Torben Schneider3, Ferran Prados1,4, Sebastien Ourselin4, Claudia Angela Wheeler-Kingshott1,5,6, and Rebecca Sara Samson1

1Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 3Philips UK, Surrey, United Kingdom, 4Translational Imaging Group, Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London, London, United Kingdom, 5Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 6Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy

Methods for quantitative measurement of myelin are of great interest for understanding brain tissue microstructure, and have potentially important implications in clinical settings for improved diagnosis and prognosis in demyelinating diseases. Quantitative Magnetization Transfer (qMT) has been proposed as a sensitive MRI technique for myelin mapping in the central nervous system. However, after an initial wave of interest, it has never found a successful translation into a clinical scenario, mostly due to its prohibitive scan time. Here we investigate solutions to promote the development of fast qMT protocols including simultaneous multi-slice EPI, and provide preliminary results in vivo.

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