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Abstract #5506

Investigation of tumor bed effect of radiotherapy using vessel size imaging in animal prostate cancer

Yu-Chun Lin1,2, Fang-Hsin Chen2, Gigin Lin1, YI-Ping Lin3, Ho-Kai Wang1, Jiunjie Wang2, and Chun-Chieh Wang3

1Dept. Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taiwan, 2Dept. Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, 3Dept. Radiation Oncology, Chang Gung Memorial Hospital, Linkou, Taiwan

MR-derived estimates of vessel size and vascular density were used to investigate the microvasculature change of tumor following preirradiation on tumor bed. The hypoxic area exhibited higher vessel size and reduced microvascular density compared with those in normoxic area. The alterations of the derived estimates were more pronounced in hypoxic regions. Significantly positive correlations were found between MRI and histology measurements. The vessel size imaging technique may be used as an imaging biomarker to characterize the tumor bed effect that occurs in recurrent tumor after radiotherapy.

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