Abstract #5507

Imaging white matter damage after traumatic brain injury: a high-field multimodal approach in a rat model

Maria Yanez Lopez¹, Nicoleta Baxan², Cornelius Donat¹, Marc Goldfinger¹, Peter Hellyer³, Mazdak Ghajari⁴, Steve Gentleman¹, Magdalena Sastre¹, and David Sharp¹

¹Department of Medicine, Imperial College London, London, United Kingdom, ²Biological Imaging Centre, Imperial College London, London, United Kingdom, ³Department of Bioengineering, Imperial College London, London, United Kingdom, ⁴Dyson School of Design Engineering, Imperial College London, London, United Kingdom

The aim of this work was to study white matter microstructural and molecular changes in a rat model of TBI using CEST and multi-shell diffusion NODDI techniques. Our results suggest that the FA decrease after injury is mainly caused by an increase in fiber dispersion in the white matter, as seen with OD NODDI. MT decrease in the CC suggests an insult to the lipids in the myelin sheath and the NOE signal displays contributions from haemorrhage in the injury time point. Histology work will allow for a more accurate interpretation of the imaging results.

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