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Abstract #5513

Effect of B1 Inhomogeneity propagated error of DCE MRI Data on Tumor Grading of Gliomas at 3T

Anirban Sengupta1, Anup Singh1, Rakesh Kumar Gupta2, and Pradeep Kumar Gupta2

1Centre for Biomedical Engineering, IIT Delhi, New Delhi, India, 2Radiology, Fortis Memorial Research Institute, New Delhi, India

DCE-MRI data is generally acquired using spoiled gradient Recalled(SPGR) echo sequence which is highly sensitive to B1 inhomogeneity. The error introduced due to B1 inhomogeneity effect on SPGR sequence is propagated to various perfusion parameters calculated in DCE-MRI. These parameters are used in various clinical analysis such as grading of tumor patients. This study had evaluated the change in perfusion parameters due to B1 inhomogeneity on 35 patients. Further simulations were done to evaluate its clinical significance. This study concluded that the change in perfusion parameters because of B1 inhomogeneity can change grading of glioma patients.

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