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Abstract #5514

Application of spin and gradient-echo (SAGE) sequence for renal perfusion imaging

Chengyan Wang1,2, Hanjing Kong2, Fei Gao3, Li Jiang4, Jue Zhang2,3, and Xiaoying Wang2,5

1Institute for Medical Imaging Technology, Shanghai Jiao Tong university, Shanghai, China, 2Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, 3College of Engineering, Peking University, Beijing, China, 4Philips Healthcare, Suzhou, China, 5Department of Radiology, Peking University First Hospital, Beijing, China

Quantification of absolute R2/R2* instead of the relative signal changes provides T1-independent perfusion imaging, which is beneficial for renal blood volume (RBV) estimations. This study applied the multiple spin- and gradient-echo (SAGE) sequence for renal perfusion imaging in ischemic acute kidney injury (AKI) animals. The results show that Both RBV and Tmax were significantly attenuated during the acute phase of AKI. R2/R2*-derived RBVs were significantly lower in the AKI kidney than that in the healthy contralateral kidney. Both R2-based and R2*-based perfusion imaging can be used to detect renal injury in AKI animals.

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