In this work we develop a high spatiotemporal resolution (spatial ~ 1.0 mm3, temporal ~ 1.6 sec) simultaneous DCE MRA and perfusion within a single 4D acquisition exploiting kinetic model based signal priors. It is demonstrated that the proposed, high spatiotemporal resolution DCE MRI, which enables rapid sampling of AIF, depicts microvascular permeability in pathological tissues (e.g., tumor) much more accurately than conventional DCE MRI (temporal resolution: 5.0 sec).
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