Abstract #5519

High SpatiotemporalResolution DCE MRA and Perfusion in a Single 4DAcquisition Exploiting KineticModel Based Signal Priors

Eun Ji Lim¹, Joon Sik Park¹, Eung Yeop Kim², Chul-Ho Sohn³, and Jaeseok Park¹

¹Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea, ²Department of Radiology, Gacheon University Gil Medical Center, Incheon, Republic of Korea, ³Department of Radiology, Seoul National University, Seoul, Republic of Korea

In this work we develop a high spatiotemporal resolution (spatial ~ 1.0 mm3, temporal ~ 1.6 sec) simultaneous DCE MRA and perfusion within a single 4D acquisition exploiting kinetic model based signal priors. It is demonstrated that the proposed, high spatiotemporal resolution DCE MRI, which enables rapid sampling of AIF, depicts microvascular permeability in pathological tissues (e.g., tumor) much more accurately than conventional DCE MRI (temporal resolution: 5.0 sec).

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