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Abstract #5520

Whole Brain Absolute CBF Measurements Using Ultra-Low GBCA DCE-MRI and Microsphere Model

Ka-Loh Li1, Daniel Lewis1,2, Alan Jackson1, Sha Zhao1, and Xiaoping Zhu1

1Division of Informatics, Imaging and Data Science, The University of Manchester, Manchester, United Kingdom, 2Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, United Kingdom

Previous authors have attempted to utilize the microsphere model and a maximum gradient (MG) based approach to estimate cerebral blood flow from DCE MRI data, which, however, was not widely accepted. This study developed a new methodology based on the microsphere theory and “early time points” method for mapping absolute CBF, using ultra-low contrast agent dose T1W-DCE-MRI. The new method was assessed using both computer simulation and in vivo data analysis in a patient with GBM, demonstrating that the new method performed better than previous approaches, e.g. MG-based methods, while using much lower dose than perfusion methods based on DSC-MRI.

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