Abstract #5521

Imaging ocular water inflow in the mouse with deuterium oxide MRI

Eric R. Muir^1,2, Shengwen Deng^2,3, and Shiliang Huang²

¹Ophthalmology, University of Texas Health Science Center, San Antonio, TX, United States, ²Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, United States, ³Biomedical Engineering, University of Texas at San Antonio, San Antonio, TX, United States

Abnormal intraocular fluid flow or clearance is involved with a variety of eye diseases such as diabetic retinopathy, but there is a lack of non-destructive methods to assess the permeability directly of water in the eye. In this study we investigate the feasibility of different MRI sequences for direct imaging of deuterium oxide inflow in the mouse eye. Balanced steady state free precession provided high signal to noise ratio for imaging deuterium oxide in the intraocular fluid, providing dynamic imaging of intraocular water inflow.

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