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Abstract #5522

Can ve be larger than one? A modification for asymmetric vascular permeability in Toft’s model may reveal glymphatic dysfunction in tumor

Pei-Lun Yu1, Ming Cheng1, Kun-I Chao1, Cheng-He Li1, Chi-Shiun Chiang1, Kung-Chu Ho2, Yi-Jui Liu3, Ruey-Hwang Chou4, and Fu-Nien Wang1

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Nuclear Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan, 3Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, 4China Medical University Graduate Institute of Cancer Biology, Taichung, Taiwan

The ve is limited between 0 and 1 by definition. However, we observed large ve when fitted the Toft’s model or its modified version to both Gd-DTPA and D2O perfusion MRI. In this study, we modified the ve to Pas*ve to incorporate the asymmetry permeability into model. Therefore, the region with high Pas*ve in D2O perfusion imaging may be attributed to the blocked pathway of water draining, which could be correlated to glymphatic dysfunction in tumor.

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