A quantitative kinetic model for the recently introduced high SNR multiple boli Arterial Spin Labelling technique (mbASL) has been developed and validated both theoretically and experimentally. By varying the labelling inversion thickness, mbASL signal was shown to switch from a pseudo-continuous to a pulsed ASL behaviour. The model reflects the hybrid nature of mbASL, which combines the high labelling efficiency of pulsed ASL with the continuous labelling advantage of pseudo-continuous ASL. We use the mbASL kinetic model produce high SNR cerebral blood flow maps based on mbASL measurements.
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