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Abstract #5530

Accounting for pCASL labelling efficiency variation in patients with low and high arterial blood flow velocities

Lena Vaclavu1, Magdalena Sokolska2, Aart J Nederveen1, and David L Thomas2

1Radiology & Nuclear Medicine, Academic Medical Center, Amsterdam, Netherlands, 2Institute of Neurology/Centre for Medical Image Computing, University College London, London, United Kingdom

Pseudo continuous arterial spin labelling (pCASL) suffers from reduced labelling efficiency in extreme flow conditions. In this work we investigated the sensitivity of labelling efficiency to velocity values measured in vivo to ascertain its variability over a clinically relevant range of velocities. We measured arterial blood velocity in the neck at the level of the labelling plane, and obtained simulated labelling efficiency values, which we found to differ significantly between high and low velocity populations. Changes in labelling efficiency induced by acetazolamide administration may have implications for future work using pCASL for cerebrovascular reserve assessments.

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