The neural mechanisms underlying over active bladder are not fully understood. In addition, the neural network involved in bladder control hasn’t been identified. In this study, we looked at resting-state functional MRI of healthy females as a function of bladder filling, utilizing fractional amplitude of low frequency fluctuation (fALFF) and seed-based functional connectivity measures. Our results demonstrate modulated activation amplitude and functional connectivity throughout the brain, primarily characterized by increases in the anterior brain, furthering our understanding of bladder control and setting the foundation for additional higher level analyses.
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