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Abstract #5573

Alterations of regional homogeneity in poststroke aphasia

Hui Zhang1, Ying Chen2, Ruiping Hu2, Liqing Yang2, Mengxing Wang1, Jilei Zhang1, Yi Wu2, and Xiaoxia Du*1

1Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai, China, 2Department of Rehabilitation Medicine, Huashan Hospital, Shanghai, China

The purpose of this study was to investigate intrinsic local synchrony changes in poststroke aphasia patients during resting-state fMRI scans. Fifteen patients (aged, 39-62 years, 4 female) and 30 age- and gender-matched healthy controls participated. Regional homogeneity (ReHo) was calculated to measure spontaneous brain activity. The results showed that poststroke aphasia patients exhibited significantly increased ReHo in the left frontal lobe, left cingulate gyrus, left corpus callosum, left temporo-parietal areas and right middle frontal gurus. Our study showed patterns of intrinsic local synchronization are altered in poststroke aphasia patients at resting state.

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