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Abstract #5578

BOLD activation pattern of cerebrum for unilateral and bilateral wrist extension task among stroke patients and healthy subjects

Neha Singh 1, Dixit Sharma 1, Megha Saini 2, Sneh Anand 1, Nand Kumar 3, MV Padma Srivastava 4, S Senthil Kumaran 5, and Amit Mehndiratta1

1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Department of Biomedical Engineering, All India Institute of Medical Sciences, NEw Delhi, India, 3Department of Psychiatry, All India Institute of Medical Sciences, NEw Delhi, India, 4Department of Neurology, All India Institute of Medical Sciences, NEw Delhi, India, 5Department of Nuclear Magnetic Resonance, All India Institute of Medical Sciences, NEw Delhi, India

Role of wrist-extension in motor control in upper-limb post-stroke recovery is significant. We compared neural structures controlling unilateral versus bilateral movement of wrist-extension task using fMRI in 6 healthy-volunteers and 6 stroke-patients. Significant BOLD activation was observed in PG during all three tasks in healthy-volunteers. Activation with bilateral-task were considerably higher than unilateral-task. In patients with stroke as a result of re-organization, ipsi-lesion cerebellum-area shows activation for affected-hand movement not present in healthy-volunteers, supporting evidence for advantages of bilateral-training in functional imaging. Knowledge of reorganization-pattern for coordinated-movement involved in bilateral-tasks may be helpful in addressing the rehabilitation of stroke-patients.

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