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Abstract #5596

Physiomechanical noise in brain magnetic resonance elastography

Charlotte A Chaze1 and Curtis L Johnson1

1Department of Biomedical Engineering, University of Delaware, Newark, DE, United States

Magnetic resonance elastography (MRE) is an emerging MRI technology that enables in-vivo quantitative assessment of tissue stiffness, which changes with age and in disease states. The accuracy and precision of brain MRE property maps are generally noise-limited; however, most noise assessments don’t appropriately consider contributions from physiological and mechanical noise sources, such as cardiac pulsation, table shaking, and imperfect actuation. In this work, we designed and carried out experiments to isolate these sources of noise. We found increasing noise from physiological vibration sources with varying behavior through space and time.

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