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Abstract #5597

Wave propagation in multi-excitation magnetic resonance elastography of the brain

Daniel R Smith1, Philip V Bayly2, Anthony J Romano3, and Curtis L Johnson1

1Biomedical Engineering, University of Delaware, Newark, DE, United States, 2Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, United States, 3Naval Research Laboratory, Code 7160, Washington, DC, United States

MR elastography (MRE) is capable of measuring the mechanical properties of the human brain; however, MRE generally assumes isotropic properties and misses the anisotropic behavior of brain white matter. Anisotropic MRE methods are under development, and the use of multiple wave propagation directions is likely necessary for accurate inversion. In this work, we characterize waves in brain MRE from multiple excitations and evaluate whether sufficient wave propagation is present. We find that multi-excitation MRE motion fields in the brain exhibit wave content in white matter tracts sufficient for anisotropic inversion.

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