A method is proposed for the correction of insufficient spoiling of transverse magnetization components in gradient echo data that are used for T1 quantification via the variable flip angle (VFA) approach. The method is based on the use of modified flip angles in the VFA algorithm that differ from the actual angles. The advantage is the versatility of the proposed method: from a given set of 21 values P(k,l), suitable correction parameters can be derived for any VFA protocol. In vitro and in vivo experiments show that this novel correction technique considerably increases the accuracy of measured T1 values.
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