Magnetisation transfer (MT) has been found to contribute to parameter estimation bias in sequences used in the two-pool relaxometry technique, mcDESPOT. Recent work shows that using controlled saturation magnetisation transfer (CSMT) RF-pulses, a two-pool system (free- and bound-pools) can behave as a single pool with modified equilibrium magnetisation and longitudinal relaxation rate. Here, we investigate the use of CSMT to model MT-effects in a three-pool system (exchange + MT) and show that under these conditions, signal behaves as a two-pool system and matches a mcDESPOT model but characterised by different parameters than those originally assumed.
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