Meeting Banner
Abstract #5651

Controlling magnetisation transfer and exchange effects in mcDESPOT relaxometry.

Daniel J. West1, Rui Pedro A. G. Teixeira1, Jacques-Donald Tournier1, Joseph V. Hajnal1, and Shaihan J. Malik1

1Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Magnetisation transfer (MT) has been found to contribute to parameter estimation bias in sequences used in the two-pool relaxometry technique, mcDESPOT. Recent work shows that using controlled saturation magnetisation transfer (CSMT) RF-pulses, a two-pool system (free- and bound-pools) can behave as a single pool with modified equilibrium magnetisation and longitudinal relaxation rate. Here, we investigate the use of CSMT to model MT-effects in a three-pool system (exchange + MT) and show that under these conditions, signal behaves as a two-pool system and matches a mcDESPOT model but characterised by different parameters than those originally assumed.

This abstract and the presentation materials are available to members only; a login is required.

Join Here