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Abstract #0002

3D Magnetic Resonance Spirometry

Tanguy Boucneau1,2,3, Brice Fernandez4, Peder Larson5, Luc Darrasse1,2,3, and Xavier Maître1,2,3

1IR4M, CNRS, Orsay, France, 2IR4M, Univ. Paris-Sud, Orsay, France, 3IR4M, Université Paris-Saclay, Orsay, France, 4Applications & Workflow, GE Healthcare, Buc, France, 5Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

Spirometry is a routine tool in pulmonology to challenge lung function. It is sensitive and specific to several common lung diseases. Nevertheless, spirometry provides a global measurement at the mouth that only characterizes the pulmonary response as a whole, and cannot specifically address regional affections. We developed a 3D MRI-based technique to non-invasively perform local spirometry throughout the lung. The final outcome is a 3D map with voxel-wise flow-volume loops over the organ. The potential of this technique is demonstrated by its sensitivity to normal, thoracic, and diaphragmatic breathings and its related regional specificity in a healthy subject.

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