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Abstract #0009

The Accuracy of Hyperpolarized 129Xe Ventilation Derived from 3D Radial Gas Exchange MRI versus Multi-Slice Gradient Echo Imaging

Mu He1,2, Ziyi Wang2,3, Leith Rankine2,4, Elianna A Bier2,3, John Nouls2, and Bastiaan Driehuys2,4

1Department of Electrical Engineering and Computer, Duke University, DURHAM, NC, United States, 2Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, 3Department of Biomedical Engineering, Duke University, DURHAM, NC, United States, 4Department of Medical Physics, Duke University, DURHAM, NC, United States

Both multi-slice GRE and 3D-radial acquisitions can image regional ventilation in the lungs. Here, we sought to evaluate the accuracy of the ventilation images acquired as part of a 3D-radial gas-exchange acquisition by comparing them with those acquired with a standard GRE acquisition. Linear-binning quantification was applied on both acquisitions to derive the quantitative metrics, through which we found good qualitative and modest pixel-wise agreement between the two ventilation scans. With further reconciliation of bias-field correction and threshold-setting for the 3D-radial pipeline, it could become a one-stop shop for single-breath ventilation and gas exchange imaging.

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