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Abstract #0031

Increased brain perfusion in neonatal hypoxic ischemic injury with negative reading of DWI, T1/T2-weighted images: Implications of perfusion MRI for reperfusion response monitoring and prognostication

Qiang Zheng1,2, Minhui Ouyang1, Juan Sebastian Martin-Saavedra1, Sandra Saade-Lemus1, Qinlin Yu1, Raymond Wang Sze1, John Flibotte1,3, John Detre3, Hao Huang1,3, and Misun Hwang1,3

1Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Yantai University, Yantai, China, 3University of Pennsylvania, Philadelphia, PA, United States

Brain perfusion plays an important role in the diagnosis and prognosis of neonatal hypoxic ischemic injury (HII). However, the studies on perfusion changes in HII neonates with negative reading in conventional magnetic resonance imaging (MRI) (HII-) are rarely reported. Here, we used arterial-spin-labeled perfusion MRI to compare cerebral blood flow among health controls, HII neonates with positive reading of conventional MRI images (HII+) and HII- neonates. The results demonstrate that perfusion is altered in HII neonates even with negative reading of conventional MRI images, suggesting importance of inclusion of perfusion MRI for evaluating HII in clinical practice and research.

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