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Abstract #0032

Music in preterm infants enhances maturation of neural pathways involved in emotion processing

Joana Sa de Almeida1, Lara Lordier2, Benjamin Zollinger3, Nicolas Kunz4, Matteo Bastiani5,6, Laura Gui7, François Lazeyras7, and Petra S. Hüppi2

1Division of Development and Growth, Department of Pediatrics, University of Geneva, Geneva, Switzerland, 2Division of Development and Growth, Department of Pediatrics, Geneva University Hospitals, Geneva, Switzerland, 3Psychology, Yale University, New Haven, CT, United States, 4Center of BioMedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 5Wellcome Centre for Integrative Neuroimaging (WIN) - Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), University of Oxford, Oxford, United Kingdom, 6Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 7Center of BioMedical Imaging (CIBM), University of Geneva, Geneva, Switzerland

Prematurity disrupts brain maturation during a critical period of development and music potentially enhances cognitive-socio-emotional pathways affected by prematurity. Using multi-modal MRI, we evaluated the structural impact of a music intervention during NICU stay in preterm infants’ brains, namely in WM through DTI ROI and tractography analysis and in amygdala through volumetric analysis. Overall, WM microstructural maturity was decreased in preterm control vs full-term newborns. In comparison to preterm control, preterm exposed to music demonstrate improved WM maturation in uncinate fasciculus, external capsule/claustrum/extreme capsule and larger amygdala volumes, proving a structural effect of music intervention on emotional processing neural pathways.

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